av SA Gruppen — Lundström S, Zachrisson U. When nothing helps: propofol as sedative and antiemetic in palliative cancer care. J. Pain Symptom Manage 20:570-577, 2005. 14.

Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Post operative nausea and vomiting (PONV) remains one of the most common and distressing complications after surgery resulting in pain, hematoma and wound dehiscence. Furthermore, small dose of Antiemetic effect of propofol Antiemetic effect of propofol Borgeat, A. 1996-11-01 00:00:00 W.G. NOTCUTT I read with interest H.F. Seeleyâ s article (Anaesthesia 1996; 51: 571-4) on the causes and outcome of stress amongst anaesthetists. Anaesthesia is a stressful specialty and if stress-associated conditions are more common in anaesthetists Propofol decreased synaptic transmission in the olfactory cortex in an animal study, suggesting a decrease in the release of excitatory amino acids such as glutamate and aspartate, which may be related to its antiemetic activity [ 14 ].

Antiemetic effect of propofol

(Anaesthesia 1996; 51: 554-7) dealing with infusions of subhypnotic doses of propofol for the prevention of postoperative nausea and vomiting. It is interesting to note that the authors found no differences between the infusions Antiemetic effect of propofol administered at the end of surgery in laparoscopic assisted vaginal hysterectomy. Antiemetic effect of propofol administered at the end of surgery in laparoscopic assisted vaginal hysterectomy. BACKGROUND: Postoperative nausea and vomiting (PONV) commonly occur after general anesthesia, especially in women. There is evidence that the antiemetic effect of propofol is associated with a defined plasma concentration range; mean, 343 ng/mL (10–90% confidence intervals [CI] 200–600 ng/mL).

frequency of Postoperative Nausea and Vomiting (PONV) between propofol and isoflurane based anesthesia in patients only the antiemetic effect of propofol.

In a double-blind, randomized trial, Honkavaara et al. compared the antiemetic efficacy of thiopental (1.0 mg/kg) versus propofol (0.5 mg/kg) administered at the end of middle ear surgery, a procedure often associated with emetic sequelae[]. Although propofol was initially accepted as an induction and maintenance hypnotic agent, its clinical use has remarkably expanded over the past 30 years.

Antiemetic effect of subhypnotic doses of propofol after thyroidectomy Postoperative nausea and vomiting (PONV) are unpleasant, often underestimated side effects of anaesthesia and surgery, not devoid of medical complications. Prevention with antiemetics is only partially effective.

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Propofol has been shown recently to possess antiemetic properties in several situations. In this prospective, randomized, controlled trial, we have compared the antiemetic efficacy of subhypnotic doses of propofol, with Intralipid as placebo, after thyroidectomy. Antiemetic effect of propofol Anaesthesia is a stressful specialty and if stress-associated conditions are more common in anaesthetists than in other hospital specialists this may be partly due to the lower status and prestige which has historically dogged the profession, especially in comparison to our surgical colleagues.
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In addition to these picture-only galleries, you Propofol is known to possess direct antiemetic effects. Its use for induction and maintenance of anaesthesia has been shown to be associated with a lower incidence of postoperative nausea and vomiting (PONV) when compared to any other anaesthetic drug or technique. However, its mechanism of action in this context is still not well understood. Propofol has been shown recently to possess antiemetic properties in several situations. In this prospective, randomized, controlled trial, we have compared the antiemetic efficacy of subhypnotic doses of propofol, with Intralipid as placebo, after thyroidectomy.

In a double-blind, randomized trial, Honkavaara et al. compared the antiemetic efficacy of thiopental (1.0 mg/kg) versus propofol (0.5 mg/kg) administered at the end of middle ear surgery, a procedure often associated with emetic sequelae[].The subhypnotic dose of propofol provided superior prophylaxis against retching and vomiting during the The exact mechanism by which propofol acts as an antiemetic remains unclear, but propofol is not considered to have vagolytic properties. 9 In addition, the efficacy of propofol as an antiemetic is not based on the lipid emulsion in the formulation of propofol.
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Intralipid, the excipient of propofol, was chosen as placebo as it is devoid of antiemetic effects. Sedation scores, respiratory and cardiovascular variables, and incidence of PONV were assessed every 4 h for 24 h. Pulse oximetry and ECG were monitored continuously.

39p. (Comprehensive Summaries of Uppsala Dissertations from Glucocorticoids may exert beneficial effects in MCAD, including a decrease in Propofol.

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Glucocorticoids may exert beneficial effects in MCAD, including a decrease in Propofol. Ketamine. Etomidate. Midazolam. Cis-atracurium. Vecuronium of a continuous infusion, patient-controlled antiemetic pump for children receiving

One study reported that propofol reduces PONV by blocking the 5-hydroxy-tryptamin-3 receptor of the serotonergic system, 20 , 21 while others reported that inhibition of the chemoreceptor trigger zone and vagal nuclei, which are directly related to nausea and vomiting, is associated with the 2014-09-16 anaesthesia with propofol is associated with a lower incidence of PONV when compared with inhalational anaesthetic. However, it is unclear regarding the dose response of propofol when used as an antiemetic, and how propofol should be administered in the perioperative period for its antiemetic effects. Antiemetic efficacy of propofol 257 same as described previously.8 9 Three different PONV outcomes were extracted in dichotomous form (i.e. presence or absence of PONV): nausea, vomiting the effect of propofol, as an induction agent or as a maintenance regimen, Postoperative nausea and vomiting (PONV) is still a clinical problem and its incidence is unacceptably high. After the introduction of propofol as an agent for induction and maintenance of anesthes Propofol may have a direct depressant effect on the chemoreceptor trigger zone, the vagal nuclei, and other centers implicated in nausea and vomiting.